Novel Hemoglobin Variant [β66(E10) Lys→Asn], with Decreased Oxygen Affinity, Causes Falsely Low Hemoglobin A1c Values by HPLC
نویسندگان
چکیده
منابع مشابه
A novel hemoglobin, Bonn, causes falsely decreased oxygen saturation measurements in pulse oximetry.
BACKGROUND A 4-year-old boy and his father exhibited low oxygen saturation measured transcutaneously by pulse oximetry, a finding that could not be confirmed by arterial blood gas analysis. Both patients exhibited slight hemolysis in their blood, and the boy had a microcytic anemia. There was no evidence of hypoxemia or methemoglobinemia. Despite the normal results from the arterial blood gas a...
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In Hb Warsaw Val replaces the Phe normally present at the heme contact position ,842 (CDl). This variant is unstable, and it readily undergoes methemoglobin formation. In DEAE-cellulose chromatography, the variant hemoglobin co-eluted with Bb A; a partially heme-depleted fraction of the variant, representing 56% of the total hemoglobin, eluted separately and in pure form. The heme replete form ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2003
ISSN: 0009-9147,1530-8561
DOI: 10.1373/49.8.1412